Can DNA differ from one sibling to another? The experts say “YES”. From an article posted by Anna Swayne on March 5, 2014 on Ancestry.com titled, “Understanding Patterns of Inheritance: Where Did My DNA Come From? (And Why It Matters.)” we read:Your DNA contains a record of your ancestors, but you aren’t a carbon copy of any one of them. The particular mix of DNA you inherit is unique to you. You receive 50% of your DNA from each of your parents, who received 50% of theirs from each of their parents, and so on. In the chart below [you will need to click on the link to the article to see the chart] you can see how the amount of DNA you receive from a particular ancestor decreases over generations. If you go back far enough, there is a chance that you inherited no DNA from a particular ancestor.